Soy Isoflavones

Soy Isoflavones – Benefits and Risks from Nature’s Selective Estrogen Receptor Modulators (SERMs)

Kenneth D. R. Setchell, PhD

Department of Pediatrics, Children’s Hospital Medical Center, Cincinnati, Ohio [SETCK0@CHMCC.ORG]

Phytoestrogens have become one of the more topical areas of interest in clinical nutrition. These non-nutrient bioactive compounds are ubiquitous to the plant kingdom and possess a wide range of biological properties that contribute to the many different health-related benefits reported for soy foods and flaxseeds – two of the most abundant dietary sources of phytoestrogens. Continue reading

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Iron Deficiency in Women of Childearing Age

Dietary and Supplement Treatment of Iron Deficiency Results in Improvements in General Health and Fatigue in Australian Women of Childbearing Age

Amanda J. Patterson, PhD, Wendy J Brown, PhD, and David C.K. Roberts, PhD

Research Centre for Gender and Health (A.J.P, W.J.B.), Discipline of Nutrition and Dietetics, Faculty of Medicine and Health Sciences (D.C.K.R.), The University of Newcastle, NSW, School of Human Movement Studies (W.J.B.), The University of Queensland, QLD, AUSTRALIA [whajp@alinga.newcastle.edu.au]

Objective: To examine the effects of iron deficiency and its treatment by iron supplementation or a high iron diet on fatigue and general health measures in women of childbearing age. Continue reading

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Cinnamon-derived Hydroxychalcone in Adipocytes

A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 Adipocytes

Karalee J. Jarvill-Taylor, PhD, Richard A. Anderson, PhD, and Donald J. Graves, PhD

Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa (K.J.J.-T., D.J.G.), Human Nutrition Research Center, ARS, USDA, Beltsville, Maryland (R.A.A.) [djgraves5@yahoo.com]

Objectives: These studies investigated the ability of a hydroxychalcone from cinnamon to function as an insulin mimetic in 3T3-L1 adipocytes. Continue reading

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Monounsaturated Fat and LDL

Effects of Monounsaturated Enriched Sunflower Oil on CHD Risk Factors Including LDL Size and Copper-Induced LDL Oxidation

Emma L. Ashton, PhD, James D. Best, MD, and Madeleine J. Ball, MBBCh, MD

School of Biomedical Sciences, University of Tasmania, Tasmania (E.L.A., M.J.B.), Department of Medicine, St. Vincent’s Hospital, Fitzroy, Victoria (J.D.B.), AUSTRALIA [Madeleine.Ball@utas.edu.au]

Objective: To compare the effects of a diet high in monounsaturated enriched sunflower oil and a low fat diet on CHD risk factors including in vitro Cu-induced LDL oxidation and LDL size, lipids, lipoproteins, glucose and insulin. Continue reading

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Safety of Phytosterol Esters

Safety and Tolerability of Esterified Phytosterols Administered in Reduced-Fat Spread and Salad Dressing to Healthy Adult Men and Women

Michael H. Davidson, MD, Kevin C. Maki, PhD, Denise M. Umporowicz, MS, Kate A. Ingram, MPH, RD, Mary R. Dicklin, PhD, Ernst Schaefer, MD, Richard W. Lane, PhD, Judith R. McNamara, MT, Judy D. Ribaya-Mercado, PhD, Gayle Perrone, MBA, Sander J. Robins, MD, and William C. Franke, PhD

Chicago Center for Clinical Research, Chicago, Illinois (M.H.D., K.C.M., D.M.U., K.A.I., M.R.D.), Lipton, Englewood Cliffs, New Jersey (R.W.L., W.C.F.), Boston VA Medical Center (S.J.R.), Tufts University (E.S., J.R.M., J.D.R.-M., G.P.), Boston, Massachusetts [kmaki@protocare.com]

Objective/Design: The safety and tolerability of three levels of plant sterol-esters administered in reduced-fat spread and salad dressing vs. control products were evaluated in this randomized, double-blind, four-arm parallel study. Continue reading

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