Can Dietary Methionine Restriction Increase the Effectiveness of Chemotherapy in Treatment of Advanced Cancer?
Daniel E. Epner, MD
Baylor College of Medicine, Houston, Texas [depner@bcm.tmc.edu]
Most metastatic tumors, such as those originating in the prostate, lung, and gastrointestinal tract, respond poorly to conventional chemotherapy. Novel treatment strategies for advanced cancer are therefore desperately needed. Continue reading
Calcium Modulation of Hypertension and Obesity: Mechanisms and Implications
Michael B. Zemel, PhD
Departments of Nutrition and Medicine, University of Tennessee, Knoxville, Tennessee [mzemel@utk.edu]
Regulation of intracellular calcium plays a key role in hypertension and obesity. Dysregulation of calcium homeostasis appears to be a fundamental factor linking these conditions. Regulation of intracellular calcium in key disease-related target tissues by calcitrophic hormones provides the opportunity to modulate disease risk with dietary calcium. Continue reading
Dietary Effects on Cardiovascular Disease Risk Factors: Beyond Saturated Fatty Acids and Cholesterol
Robert J. Nicolosi, PhD, FACN, Thomas A. Wilson, PhD, MPH, Carl Lawton, PhD, and Garry J. Handelman, PhD
Departments of Health and Clinical Science and Chemical Engineering, Center For Chronic Disease Control and Prevention, University of Massachusetts-Lowell, Lowell, Massachusetts [Robert_Nicolosi@uml.edu]
Hypercholesterolemia represents a significant risk for cardiovascular disease (CVD). While diet intervention remains the initial choice for the prevention and treatment of CVD, the nature of the dietary modification remains controversial. Continue reading
Nutraceutical Fatty Acids as Biochemical and Molecular Modulators of Skeletal Biology
Bruce A. Watkins, PhD, FACN, Yong Li, PhD, and Mark F. Seifert, PhD
Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, and Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana [watkins@foodsci.purdue.edu]
Several systemic hormones and localized growth factors coordinate events of bone formation and resorption to support bone growth in the young and maintain bone mineral content in the adult. Continue reading
Constructive Interactions among Nutrients and Bone-Active Pharmacologic Agents with Principal Emphasis on Calcium, Phosphorus, Vitamin D and Protein
Robert P. Heaney, MD
John A. Creighton University Professor, Creighton University, Omaha, Nebraska [rheaney@creighton.edu]
Current and emerging bone active pharmacologic agents are capable of producing substantial gains in bone mass. However, nutrition must be adequate if this potential is to be realized. Calcium and vitamin D supplementation, for example, have both been demonstrated to augment substantially the skeletal response to estrogen therapy in postmenopausal women. Continue reading
